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Bioavailability is approximately 89%, meaning almost all of the dose reaches the bloodstream A single 2.4mg weekly injection maintains consistent therapeutic levels throughout the week Your diet, other medications, time of injection, etc., do not affect the absorption The injections require refrigeration at 28C (can be kept at room temperature for up to 6 weeks once in use) If youre a user, youre most probably familiar with all of these facts
Shank2 knockout mice (e67 KO) exhibit decreased expression levels of Gabra2 and GABA receptor-mediated inhibitory signaling, which can be reversed by treatment with allosteric modulators of GABA-ARs (99, 100)
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