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Changes in Borrelia burgdorferi -specific serum IgG antibody levels in patients treated for acrodermatitis chronica atrophicans

This process is marked by chronic low-grade inflammation (inflammaging), diminished adaptive immunity, and a skewed CD4+/CD8+ T cell ratio, leaving older adults more vulnerable to infection, cancer, and poor vaccine responses [47]

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Age also impacts hepatotoxicity risk, with advanced age (over 40 years old) being associated with a higher risk of acute liver failure, liver transplantation, and death from paracetamol overdose[50]