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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

van Raaij S, van Swelm R, Bouman K, Cliteur M, van den Heuvel MC, Pertijs J, et al

I.et al (2014)

Humans express two genes that generate glucose-6-phosphate dehydrogenase activity, the X-linked G6PD gene and an autosomal gene identified as H6PD (hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase)