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Implications for Clinical Practice Our findings suggest that integrating hormonal surveillance with individualized pharmacotherapy may enhance long-term care of adolescents post-LSG, but further research is required to establish the utility and cost-effectiveness of such strategies

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With a single molecule approach, the ratio of activities of the constituents, however, will be fixed, whereas individual combination therapies present the potential benefit of being titratable to allow more optimal ratio between doses of the agonists