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Tissue Repair & Skin Health Nicotinamide and Dexpanthenol assist in collagen synthesis and wound recovery

A 16-week, phase III, single-dose, randomized, double-blind, placebo-controlled clinical trial tested orally administered curcumin in 63 patients with mild-to-moderate chronic plaque psoriasis (absolute PASI 30 ng/mL) and supplement to boost levels into the adequate range if not

[3,10] Collagen is the structural protein in tendons, ligaments, and connective tissue more collagen synthesis means stronger, faster structural repair

Gastrointestinal effects are the most frequently reported side effects and include: Nausea (1224% of patients): Often most pronounced during treatment initiation and dose escalation, typically improving over time Diarrhea (1323% of patients): May be transient or persistent, requiring dietary modifications Vomiting (611% of patients): Can lead to dehydration if severe or prolonged Constipation (617% of patients): May require increased fiber intake and hydration Abdominal pain or discomfort (610% of patients): Usually mild to moderate in severity Decreased appetite : Therapeutic effect but may be excessive in some individuals These gastrointestinal symptoms generally diminish over several weeks as the body adjusts to the medication