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Accordingly, exposure microglia to palmitic acid (C16:0/PA) enhanced the expression of proinflammatory markers (Duffy et al., 2015), and a decreased in C22:0C24:0 ceramides by deletion of CerS2 triggered the activation of microglial cells and progressive myelin atrophy (Teo et al., 2023)

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Inhibition of these two enzymes can be a useful strategy for controlling blood sugar levels in people with diabetes

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