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Glutamine depletion decreases the expression of tight junction proteins in the gut and may increase intestinal permeability (when toxins from the gut can leak into the bloodstream), which can trigger the type of chronic, body-wide inflammation that underlies many metabolic disorders

In another evaluation of the FAERS data, McIntyre and colleagues observed disproportionate reporting of suicidal ideation and depression associated with liraglutide (Saxenda) and semaglutide compared to other glucose lowering agents

GLP-1s work to manage blood sugar levels by promoting insulin release only when blood glucose is elevated

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