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In the presence of ferrous ions (Fe + ), hydrogen peroxide can further generate highly reactive hydroxyl radicals through the Fenton reaction ( 2.2 Endoplasmic reticulum stress During the protein folding process, the electron transfer associated with the formation of disulfide bonds can generate ROS ( 2.3 NADPH oxidase The NADPH oxidase (Nox) family comprises seven members, namely Nox1 through Nox5, as well as Duox1 and Duox2, and plays a crucial role in the generation of ROS during inflammatory responses

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