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Although trials have confirmed that selenium supplementation results in a quarterly reduction in cardiovascular disease incidence, serum selenium concentrations above 135 ng/ml are associated with cardiovascular incidents such as ischemic stroke, myocardial infarction, and sudden cardiac death (Bleys et al

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Copper deficiency is a well-established causative factor of cardiac hypertrophy, which manifests as concentric thickening of the ventricular walls and interventricular septum, resembling pressure-overload hypertrophy [178]

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