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The improved ability to control a BCG infection for the L-GSH group, when compared to the placebo group, also correlated with significant increases in the levels of IFN- ( Figures 6B, C ) and TNF- ( Figures 6D, E ) in the supernatants of in vitro granulomas

When compared to the placebo group, PBMCs isolated from individuals with T2DM who received L-GSH supplementation for 3-months had a significantly reduced burden of BCG ( Figure 6A )

We are conscious of the limitations of the animal models [123], however in a clinical trial undertaken by this group to asses IGF-1 in liver function under cirrhosis with these same dosage (20 g/kg/day) no side effects were reported and liver function greatly increased [108]