A clinical study published in the New England Journal of Medicine in 2024 (4) showed that, in people with excess fatty liver with mild to moderate fibrosis , administration of semaglutide once a week for 240 weeks was correlated with: improvement in liver composition and inflammation without worsening of fibrosis in more than 60% of cases, compared with approximately 34% of subjects on placebo reduction in scar tissue without worsening of steatohepatitis in more than 36% of patients, compared with around 22% of those on placebo resolution of steatohepatitis with a reduction in fibrosis in 32.7% of patients, compared with 16.1% in the placebo group average reduction in body weight of 10.5%, compared with just 2.0% on placebo The mechanisms that could explain these results From a medical point of view, these effects on liver health could be explained by several complementary mechanisms: a general reduction in body fat , particularly visceral fat in the abdomen and liver, a criterion often associated with improvements in liver parameters (5) a reduction in oxidative stress , known to damage liver cells (6) Although potentially interesting for supporting liver function , GLP-1 agonists are drug treatments that can have side effects (7)
In another randomized, double-blind, placebo-controlled trial, twice-daily supplementation with 250 mg of magnesium oxide plus 220 mg of zinc sulfate (equivalent to 50 mg elemental zinc) for 12 weeks significantly reduced serum hs-CRP and protein carbonyl (PCO) levels and markedly elevated plasma TAC compared with the placebo (106)
Risks and Benefits: Discomfort is minimal due to injections of local anaesthetic, but there is often some swelling and mild bruising in the treated area for a week or so
L-theanine may improve sleep quality by promoting relaxation and reducing anxiety without causing drowsiness during the day
