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Exendin 939 does not affect TRPV1 activation via protons, suggesting its mode selectivity As the inhibitory effect of exendin 939 on CAP-induced activation of TRPV1 was confirmed, its effect on proton-induced activation of TRPV1 was also tested via patch-clamp recordings and calcium imaging

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Also, its unclear whether dual receptor activation will outperform standard GLP-1 agents in treating addiction