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Acknowledgements This work was supported by Coordenao de Aperfeioamento de Pessoal de Nvel Superior (CAPES), Conselho Nacional de Desenvolvimento Cientfico e Tecnolgico (CNPq), Fundao de Amparo Pesquisa do Estado do Rio Grande do Sul (FAPERGS), Financiadora de Estudos e Projetos/Rede Instituto Brasileiro de Neurocincia (FINEP) and Instituto Nacional de Cincia e Tecnologia em Excitotoxicidade e Neuroproteo (INCT-EN)