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According to the Mayo Clinic, if your vitamin deficiency is severe enough to make you feel lethargic, you could gain weight as a result of reducing your exercise and movement

If you have a thyroid condition and/or any of the risk factors of B12 deficiency as outlined above, there is a very good chance that you are not properly absorbing B12, even if you eat a diet rich in animal proteins, so it is important to get tested if you suspect a deficiency

High-dose methionine supplementation has theoretical concerns regarding homocysteine elevation, though this is unlikely at typical lipotropic injection doses

If this occurs, the symptoms are typically temporary and should resolve within a day or two