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Male rats receiving 1.2 mg/kg sertraline cumulatively until postnatal day 126 exhibited significantly reduced male potency (based on various indices of mating and fertility), while cumulative treatment significantly increased the number of fetal congenital malformations and reduced the numbers of implantation sites and surviving fetuses

This results from GLP-1 receptor activation in the brainstem's chemoreceptor trigger zone, as well as delayed gastric emptying

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