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Preclinical evidence and mechanistic studies suggest that the truncated analog activates IGF-1 receptors with greater potency than native IGF-1, thereby contributing to satellite cell activation and protein synthesis in tissues at the injection site

[3] The doses used in these tendon studies typically ranged from 10 to 200 micrograms per kilogram of body weight, administered once daily, which when extrapolated to a 75-kilogram human would suggest a working range of approximately 200 to 500 micrograms per day