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Commonly reported side effects include: Nausea and vomiting Diarrhoea or constipation Reduced appetite Abdominal discomfort or bloating Belching or reflux These effects are typically most pronounced during the dose escalation phase and tend to diminish as the body adjusts to the medication

Studies use Retatrutide to examine how adding glucagon receptor co-activation to combined GLP-1/GIP agonism further influences energy balance parameters compared to dual-receptor compounds

Target dose: 250mcg

Patients who combine semaglutide with strength training and adequate protein intake during this phase tend to preserve more lean muscle and report better results long-term