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The rationale is that two smaller doses produce a more even medication level throughout the week, avoiding the peak-and-trough pattern that creates intense digestive effects early in the week and diminishing effects late in the week

Secondly, CLA can alter steroid formation by regulating gene expression of specific enzymes and transport proteins involved in synthetic testosterone production, such as 17-hydroxylase/17, 20 lyase (CYP17A1), which converts progesterone to androstenedione

[CrossRef] [Google Scholar] Global burden of 369 diseases and injuries in 204 countries and territories: A systematic analysis for the global burden of disease study 2019

Kobayashi, T., Shiba, T., Kinoshita, A., Matsumoto, T