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This version of IGF-1 acts directly on skeletal muscle and other tissues to stimulate cellular growth and protein synthesis in test models
Under conditions of severe DNA damage, PARP hyperactivation can deplete cellular NAD+ pools, reducing sirtuin activity and mitochondrial function while promoting cell death through energy depletion
Kawamura Y, Uchijima Y, Horike N, Tonami K, Nishiyama K, Amano T, Asano T, Kurihara Y, Kurihara H: Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
Yusof Y, Emery P (2013): Targeting Interleukin-6 in rheumatoid arthritis
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