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Fragmented ECM components like fibronectin and biglycan further act as damage-associated molecular patterns (DAMPs), engaging TLR2/4 on macrophages and enhancing cytokine release (139)

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doi: 10.3389/fphar.2023.1103062 Received 19 November 2022 Accepted 16 January 2023 Published 30 January 2023 Volume 14 - 2023 Edited by Norberto Perico, Mario Negri Institute for Pharmacological Research (IRCCS), Italy Reviewed by Man Livingston, Augusta University, United States Robert Louis Safirstein, Yale University, United States Updates Copyright 2023 Alassaf and Attia