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As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging

They have exhibited a wide variety of biological activities for thousands of years, including targeting mitochondrial dysfunction ( 2 Mitochondrial dysfunctions in kidney diseases 2.1 Mitochondrial homeostasis imbalance Mitochondrial quality control (MQC) is an elaborate mechanism to maintain homeostasis, ensuring the enough numbers of functional mitochondria (Figure 1)

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Bioengineered peptide-based products a newer category are designed for sustained pathway engagement