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Prescription weight loss drugs such as phentermine and topiramate (Qsymia) or bupropion and naltrexone (Contrave) are used for chronic, long-term weight loss, but only if adequate results occur

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The resulting increase in intracellular NAD+ availability activates sirtuins particularly SIRT1, which regulates insulin sensitivity, gluconeogenesis, cholesterol synthesis, and fatty acid oxidation, and SIRT3, which governs mitochondrial antioxidant defences and energy metabolism

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