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Passer, B

Epigallocatechin-3-gallate (EGCG), total flavonoids of Engelhardia roxburghiana leaves (TFERL), Lycium barbarum polysaccharide-glycoprotein (LBP), perillaldehyde (PAH), and melatonin are six distinct modalities that upregulate GPX4 expression by enhancing the NRF2 pathway, resulting in amelioration of IR-induced ferroptosis [38, 48, 92,93,94,95]

The acetylation of glutathione ensures stability and facilitates absorption, making it more effective than traditional glutathione supplements

Overall, indirect regulation strategies are more suitable as adjuvant treatments, and their true clinical value still requires validation through population studies