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Commercially available doxycycline hyclate soluble powder and DOXHCl solution we prepared were diluted with the simulated water to a final administration concentration of 300 mg/L (calculated as doxycycline) and maintained at room temperature
J Am Geriatr Soc 24:359361 Triggs EJ, Nation RL, Long A, Ashley JJ (1975) Pharmacokinetics in the elderly
Ye R, Ren A, Zhang L, et al
Moreover, hypomethylated regions of the DNA strands have been shown to demonstrate twofold signs of instability in experimental studies, whether through the raised incidence of deamination to uracil, or through the increased vulnerability to endogenous nucleases [42,43]
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