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Over time, the duration and frequency of these flares may increase, resulting in chronic gouty arthritis and subcutaneous deposits of crystals, referred to as tophi, both of which can lead to the destruction of joints and musculoskeletal disability

On the other hand, GHR ablation in the entire brain was expected to increase GH secretion due to impaired GH negative feedback

Cellular senescence is characterized by a stable arrest in the cell cycle and encompasses a range of cellular changes that culminate in the development of a complex, pro-inflammatory secretory profile known as the senescence-associated secretory phenotype (SASP), which plays a critical role in fibrosis and tumors by affecting numerous processes, including invasion and therapy resistance 10

No adverse effects on cardiac, hepatic, renal, or reproductive systems