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With more severe injury, synapse disruption, axonal injury, excitotoxicity, and cell death also become major effectors

With insulin, there is risk of weight gain, for hypoglycemia, and theres more treatment burden and need for glucose monitoring. GLP-1 drugs have also been shown to have cardiovascular benefits, she adds, though further clinical trials are needed to assess orforgliprons effects on heart health

These unit costs were used to calculate annual costs of treatment for each arm, based on the resource use from the PIONEER 2 and 3 clinical trials for comparisons with empagliflozin and dulaglutide, respectively

Rotating injection sites (abdomen, thigh, or upper arm) with each weekly dose can help minimise localised discomfort