Whats Next: Regulatory filing for weight management: by end of 2025 Submission for type 2 diabetes: expected in 2026 Drug discovered by Chugai, licensed by Lilly in 2018 Implication: Orforglipron could become the first once-daily oral GLP-1 therapy with potent glucose-lowering and weight-loss benefits, potentially disrupting the injectable incretin market.
Clinicians treating obesity should screen for the presence of eating disorder psychopathology before prescribing GLP-1RAs, as these medications are contraindicated in cases of overweight or obesity associated with atypical anorexia nervosa, bulimia nervosa, and subthreshold bulimia nervosa
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A fall, direct blow, or sudden strain may inflame or rupture the bursa
