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Pros: One-time treatment Long-term weight loss supported by decades of research Often improves diabetes, blood pressure, and sleep apnea No lifelong medication costs Cons: Requires surgery and recovery Lifestyle changes are necessary For many patients with severe obesity, bariatric surgery remains the most effective long-term treatment available

J Endocrinol 207:163175 Woolston CM, Al-Attar A, Storr SJ, Ellis IO, Morgan DA, Martin SG (2011) Redox protein expression predicts radiotherapeutic response in early-stage invasive breast cancer patients

Published binding studies have demonstrated 10-100 fold increased potency compared to native alpha-MSH at the MC1R

Defending plasma T3 is a biological priority