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Genetic variation in the GLP1R, GIPR, FTO, and MC4R genes influences how your body responds to GLP-1 therapy

Based on the STEP-1 clinical trial, the average weight loss with semaglutide 2.4 mg weekly is 14.9% of body weight over 68 weeks (about 16 months)

The sensible path is for a professional to review your full history, your other conditions, and what youve already tried, and to decide from there what makes sense for you

Those dealing with allodynia on semaglutide or GLP-1 injection site reactions should note that gut inflammation from poor microbiome health can amplify systemic inflammatory symptoms, making probiotic support even more relevant