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Mucolytics such as dornase alfa (NCT04402944, phase II of recombinant human DNase I for COVID-19) and mannitol (NCT00251056, phase II of mannitol for cystic fibrosis) have been tested mainly to relieve mucus blockages, but they do not assist drugs breakthrough or controllability interact with the mucus effectively

For a low-side-effect, pulsatile GH augmentation that respects physiologic rhythm, ipamorelin is the cleaner choice

If approved, Zepbound will be the first medication to address this unmet need in patients with OSA