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The elevated cAMP activates two primary pathways: Protein Kinase A (PKA) and Exchange Protein directly Activated by cAMP (EPAC)

GO analysis showed that potential targets of GSH were mainly associated with various biological processes, such as the positive regulation of cell migration, reactive oxygen species metabolic process, focal adhesion, PI3K-Akt-mTOR signaling pathway and MAPK signaling pathways, which have been shown to be involved in the pathogenesis of HF[26-30]

Exendin 939 does not affect TRPV1 activation via protons, suggesting its mode selectivity As the inhibitory effect of exendin 939 on CAP-induced activation of TRPV1 was confirmed, its effect on proton-induced activation of TRPV1 was also tested via patch-clamp recordings and calcium imaging