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However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment

Additionally, the BDNF-TrkB signaling pathway not only supports neuronal development and survival but also promotes the growth of dendritic spines

Where things stand (June 2026) CagriSema Phase 3 results have been reported