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The Humira patent thicket is the canonical example: AbbVie assembled more than 250 patents on adalimumab, creating a barrier that kept biosimilars out of the U.S

Subsequent efforts yielded a family of Dihexa-based molecules possessing increased hydrophobicity, decreased hydrogen bonding potential, and increased metabolic stability

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I dont know who needs to hear this: cheaper drug access is not an indication for personalized compounding