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Without adequate glutathione in the brain, reactive nitrogen species, particularly peroxynitrite, accumulate rapidly

Through these effects, omega-3 and 6 PUFA play several important roles in vision and nervous system function

These critical issues needed to be supported/defended in the application by an assessment of patient co-morbidities, patient characteristics, social system support, system capacity for primary care and disease management, and institutional issues such as finances, confounders to health care system improvement including fragmentation of services, competition, and assessment of regional planning issues

nonetheless, there are a few differences across the models