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Children at 3-6 months of age are significantly larger than newborns, which facilitates the technical requirements of the surgery and results in better aesthetic and functional outcomes

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Data limitations: No completed human efficacy trial exists for any indication, and the literatures short observation windows mean long-term safety in either animals or humans remains unestablished

6 Evidence Strength Assessment NAC has a broader and more extensively replicated human evidence base, including two published meta-analyses and RCTs across diverse clinical populations