Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood
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Although high doses of B12 are generally considered safe due to its water-soluble nature, most individuals can obtain sufficient B12 through a balanced diet that includes foods like meat, eggs, and fortified cereals
