glp-1 overview Mechanisms by which agonists may exert beneficial effects on the Indications for GLP-1/GIP RA Summary

glp-1 overview

glp-1 overview Mechanisms by which agonists may exert beneficial effects on the Indications for GLP-1/GIP RA Summary

Name: glp-1 overview Mechanisms by which agonists may exert beneficial effects on the Indications for GLP-1/GIP RA Summary
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Description

J Cell Mol Med 26(12):33233328

On one hand, increased cytochrome C release caused by mitochondrial calcium overload inhibits the negative feedback effect of cytoplasmic Ca 2+ on IP3 receptors, while on the other, it activates caspase3 to cleave IP3 receptors, hence forming a vicious cycle of massive calcium release from the ER[28]

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