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In clinical genetic practice, thus Clinical variants correspond to variants of uncertain significance (VUS) thought to be very likely to be a disease related as the reported phenotype for the gene closely matches the clinical phenotype of the patient (clinical correlation)

The article says leg cramps and muscle spasms are not routinely reported as primary side effects in semaglutide trials, where nausea, vomiting and gastrointestinal discomfort dominate the safety profile, and that musculoskeletal complaints typically occurred at rates similar to placebo

Oxid Med Cell Longev 2018:15

Secondary outcomes included major CV and kidney events, while major adverse limb events (MALE) were analyzed as an exploratory endpoint