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Imaging studies have reported functional and structural changes in the vmPFC of adolescents and young adult bipolar patients relative to healthy controls ( The ventrolateral PFC is also often referred to as the lateral orbital PFC

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This difference explains why the trial will likely be terminated early, and a more objective background risk estimation needs to be performed (if available) compared to heterogeneous prevalence studies

However, further analysis showed that those with higher diet soda intake were more likely to already have, or be at higher risk for, diabetes