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Patients who should have potassium monitoring include: Those taking diuretics particularly thiazide or loop diuretics, which promote renal potassium loss and are commonly prescribed for hypertension or heart failure (BNF) Individuals with chronic kidney disease (CKD) impaired renal function affects potassium homeostasis, and these patients may have baseline electrolyte abnormalities Patients on renin-angiotensin-aldosterone system (RAAS) inhibitors ACE inhibitors, angiotensin receptor blockers (ARBs), and mineralocorticoid receptor antagonists can affect potassium balance, though typically causing hyperkalaemia (high potassium) rather than hypokalaemia [5] [6] Those with cardiac conditions including heart failure, arrhythmias, or ischaemic heart disease, where potassium imbalance poses particular risk Patients experiencing severe or persistent gastrointestinal side effects ongoing vomiting or diarrhoea significantly increases the risk of electrolyte depletion Clinical guidelines recommend checking urea and electrolytes (U&Es) at baseline for patients in at-risk groups before starting weight management interventions