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For example, the Wnt/-catenin pathway is involved in BBB integrity, synapse assembly, synapse functions, synaptic plasticity, neurogenesis, white matter lesion remyelination, dopamine neuron neuronal survival protection, and regeneration, whereas aberrations in the Wnt/-catenin pathway are associated with synaptic loss, BBB breakdown, and neurodegenerative disease, including Alzheimers and Parkinsons disease (6468)

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