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MRI results showed mainly reversible brain atrophy with delayed myelin formation, although some patients had normal MRI findings [94,95,96]

A medication that looks normal in color could still be past its beyond-use date, contaminated with bacteria you cannot see, or degraded in potency without visible change

However, it is a quite invasive technique, and there is still a lot of uncertainty about the uptake by the brain, which might depend on brain states (e.g., awake vs anesthetized), the hydrophobicity of the compound, or its interaction with efflux transporters (Abbott et al., 2018)

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