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Signal detection based on PT levels In the Preferred Term (PT) level analysis, we implemented a rigorous screening protocol to exclude conditions that might represent therapeutic indications for GLP-1 receptor agonists and metformin combination therapy, as well as events clearly unrelated to pharmacologically-induced adverse reactions

One-week treatment of DIO mice with G49 induces a transient lipid overload in the liver, increases ketogenesis and FGF21 levels Due to the rapid increase (16 h) in circulating FFAs in G49-treated mice (Fig

NLRP3 inflammasome activation is also activated by cholesterol and oxidized low-density lipoprotein (oxLDL) (Duewell et al