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What about activities of daily living

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Moreover, a US national study of 2,806 older women (50 years) found increased plasma concentration of methylmalonic acid the metabolic indicator of vitamin B 12 deficiency to be associated with increased risk of lumbar spine osteoporosis (115)

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The biphasic response suggests possible mechanisms: lower doses (nanogram range) might work through growth factor upregulation and signaling cascade amplification, while higher doses (microgram range) might involve direct receptor activation or substrate provision for cellular repair

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None are positively listed under 21 U.S.C

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