In fact, an increase of blood glucose has not been observed so far in a clinical setting
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EMBO Rep 17(5):682694 Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL (2002) Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists