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Lancet 400(10366):18691881 Jastreboff AM, Kaplan LM, Fras JP, Wu Q, Du Y, Gurbuz S et al (2023) Retatrutide phase 2 obesity trial investigators
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53 In addition to neuroprotective potential of Ex-4 on CNS by the inhibition of apoptosis, this factor is also able to pass across the blood-brain barrier and binds to GLP-1R followed by the activation of adenylyl cyclase, PKC and mitogen-activated protein signaling pathways could regulate brain bioactivity and memory function
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