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(46) compared the efficacy of electroacupuncture, bee venom acupuncture, and OFA therapy (830 nm, 20 mW, 3 min, bilateral GB34 acupoint, three weekly sessions over four weeks) in KOA model rats

PMCID: PMC11091273 Morsali S, Sabahi Z, Kakaei J, Hakimzadeh Z, Hamidi S, Gholipour-Khalili E, Sanaie S, Talebi M, Naseri A (2023) Clinical efficacy and safety of melatonin supplementation in multiple sclerosis: a systematic review

The onset is often quite sudden, which can make it easier to identify the trigger

Its ability to preserve mitochondrial integrity, enhance cerebral perfusion, mitigate oxidative stress, and support synaptic plasticity positions it as a neuroprotective adjunct rather than a primary monoaminergic antidepressant