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Daily oral doses of 8002,000 IU (2050 g) for 23 months are recommended for adults with mild deficiency, while severe deficits are usually treated with higher doses (1,250 g) once per week for 612 weeks, followed by a lower daily intake

The constraint is tolerability: greater potency brings more gastrointestinal burden during titration, which is why the engineering of dose escalation now matters as much as efficacy

It would be interesting to see if a longer time interval between vaccinations than the 3 weeks employed in this study changes the magnitude and type of immune response generated, as it does when reboosting with Ad/MVA encoding HCV antigens [150]

Typical include temporary redness and peeling