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This is due to free radicals-induced MT-transcriptional responses through metal regulatory transcription factor 1 (MTF-1) which in the presence of Zn ions (displaced from SOD by cadmium contained in cigarette smoke), binds to a metal-responsive element in the promoter region of the MT gene to initiate its transcription (Wolfram et al

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There is also the T(-413)T genotype of rs2071746 , which has been shown to have significantly lower serum bilirubin levels in T(-413)T carriers in both the CRC group and the control group (32)

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