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However, due to the lentiginous growth pattern, multifocal nature of MM, and limitations of the specific MM anatomic sites, it is extremely difficult for surgery to achieve wide negative margins, which leads to a high local relapse rate at 50%-90% (136)

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At the same time, TGR5 signaling in TAMs supports M2-type polarization via the cAMPSTAT3/STAT6 axis, suppressing CD8 T-cell functions [134]